Supply chains face numerous vulnerabilities, accentuated by pandemics and geopolitical tensions, necessitating robust resilience strategies to enhance adaptability and reactivity. This research explores the integration of emerging technologies, such as blockchain IoT-based traceability systems, to explore the dynamic interplay among three widely used resilience strategies: collaboration, flexibility, and redundancy. Grounded in Complex Adaptive Systems (CAS) and Synergy theories, the study employs a Design Science Research framework to develop an artefact based on a hybrid simulation methodology informed by real data from a seafood supply chain. This approach uncovers how blockchain integration enhances supply chain performance and reveals the rebalanced synergistic and antagonistic effects of strategy combinations. This work contributes to the theory by investigating the interaction of resilience strategies in technology-driven supply chains. Moreover, it provides practitioners with guidelines and decision-making support to align resilience strategies with blockchain capabilities, thereby enhancing operational adaptability.