As health crises escalate at a rapid pace, the potential of Health Management Information Systems (HMIS) to drive public health decisions remains largely overlooked, especially in low-income countries where data-driven policies are most needed. This underutilization is most critical in environments where HMIS could prove to be most disruptive, significantly impacting health outcomes by informing frontline policies and interventions. A case study methodology was applied to explore the processes by which health information is transformed into informed action. By highlighting their disruptive properties, this paper shows that HMIS can be used to inform and improve the delivery of health services. The results indicate that HMIS integration contribute significantly to enhancing decision-making capabilities at strategic and operational levels. In addition, evidence was found that effective use of health information supports higher adherence to antiretroviral treatment and effective malaria control strategies.