Artificial Intelligence (AI) is widely regarded as the next frontier in creating business value, including the supply chain context. Anchored on the resource-based theory, this study investigates the role of artificial intelligence (AI) in enhancing supply chain resilience (SCR) and the mediating role of data-driven culture. Data were obtained from managers (n=136) in Middle East manufacturing firms to achieve the study objectives. Partial least squares structural equation modelling (PLS-SEM) technique was applied. The findings revealed that AI capabilities are a crucial value-adding practice that improves SCR. They also suggested that data-driven culture is a significant mediating factor in the relationship between AI capabilities and SCR. The findings can assist managers in devising suitable long-term strategies for integrating additional AI capabilities to boost SCR, especially firms navigating uncertain environments.